APOE and Alzheimer disease: However, after adjustment on APOE ε4, age, sex, education level, and tobacco consumption, and using the naMCI group as reference, we found a significant association of a lower caffeine consumption with a higher risk to be aMCI (OR: 2.72 [95% CI: 1.17 to 6.30]) and a similar effect size, even non‐significant, for higher risk of being AD (OR:2.31 [95% CI: 0.98 to 5.40]; Table 2).