In addition, immunohistochemical analysis further confirmed that APOC1, CFH, NR4A2 and NUSAP1 expression at the protein level was higher in primary PCa tissues than in PCa with bone metastasis tissues (p < 0.05) (Figure 3E,F,H), while NR4A2 exhibited the opposite trend (p < 0.05) (Figure 3G). Here, CFH is linked to posterior cortical atrophy.