In hindsight, treatment of SARS-CoV2-induced pneumonia in P1 - even prior to a genetic diagnosis - likely facilitated relatively early recovery and survival given the well-known severity of SARS-CoV2 infection in IFNAR1/IFNAR2-deficient patients [4, 5, 8, 10, 14]. Here, IFNAR1 is linked to susceptibility to pneumonia measurement.