CD4 and Huntington disease: Typical DOCK8-deficient patients have an inverted CD4:CD8 ratio (~ 1:2 vs. 2–3:1 for HD), and aberrant CD4+ and CD8+ T cell compartments (reduced naïve cells/increased TEM and TEMRA cells) compared to HDs [18, 20, 21] (Fig. 3A-C, upper and middle panels; Fig. 3D, E).