Raturi et al. demonstrated that ER-localized thioredoxin-related transmembrane protein 1(TMX1) targeting ERMMDs in a palmitoylation-dependent manner enhances mitochondrial ATP production and induces apoptosis in tumor cells by modulating the number of ER-mitochondria contacts and intracellular ER-mitochondria Ca2+ flux, thereby inhibiting tumor growth [84]. The gene discussed is TMX1; the disease is neoplasm.