In particular, in CRC cell lines HCT116, it has been shown through chromatin immune precipitation that nuclear RAC1B, is recruited to the promoters of Wnt target genes c-Myc and Cyclin D1, acting as co-activator in B-catenin/TCF-mediated transcription enhancing the expression of the indicated genes [18, 30, 31]. Here, HNF4A is linked to colorectal carcinoma.