In RCC, FTO promotes angiogenesis by inhibiting von Hippel-Lindau tumor suppressor (VHL) expression, whereas in intrahepatic cholangiocarcinoma (ICC), FTO suppresses angiogenesis by inducing TEA domain transcription factor 2 (TEAD2) expression [59, 60]. This evidence concerns the gene TEAD2 and intrahepatic cholangiocarcinoma.