3) Regulation of neurohormones and neurotrophic factors: Promotion of neurotrophic factors [43], such as brain-derived neurotrophic factor, plays an important role in sleep disorders; in the meantime, neurohormones such as pregnanolone, allopregnanolone and pregnenolone are involved in the generation of slow wave sleep [44]. The gene discussed is BDNF; the disease is sleep disorder.