CD4 and cancer: Distinct phenotypes of CAFs have been described: inflammatory CAF (iCAFs), located further from cancer cells and expressing cytokines, myofibroblastic CAF (myCAFs), which can be found in direct proximity to cancer cells and are characterized by the expression of αSMA10, and antigen-presenting CAFs, which can act in a immunomodulatory manner via activation of CD4 + T cells22.