Zhou et al. reported that Notch-dependent signaling could control myelopoiesis, and fucosylation of Notch could regulate the ligand binding activity and efficiency of Notch signaling in myeloid progenitors.102O-fucose site mutations have been found in anaplastic large cell lymphoma as two mutations in NOTCH1 (p.T311P and p.T349P) result in deletion of the O-fucose site in the eighth and ninth EGF repetitive sequences in the NOTCH1 ECD.103 Furthermore, certain O-fucose molecules are elongated through the activity of β-1,3-N-acetylglucosaminyltransferases (β3GNTs) from the Fringe family. The gene discussed is NOTCH1; the disease is anaplastic large cell lymphoma.