POFUT1 and acute myeloid leukemia: This mutation is known to induce decreased O-glucosyltransferase activity on Notch receptors, leading to impaired muscle development.94 POFUT1 is localized in the region of 20q11.21, which is heavily amplified in acute myeloid leukemia (AML).95 Recent findings indicate that POFUT1, the enzyme responsible for adding O-fucose to Notch receptors, may also play a role in quality control within the ER.