Glycosylation of PD-L1 is a major mechanism that induces its stabilization, reduces the detection by PD-L1 antibody and consequently results in immune escape.222 Removing the N-linked glycosylation significantly enhanced anti-PD-1/PD-L1 therapy efficacy.223 In addition, changes in glycosylation patterns in lung cancer cells also have potential as biomarkers for early diagnosis and prognosis. Here, CD274 is linked to lung cancer.