MYC and leukemia: High levels of C-Myc expression promote leukemia cells to enhance self-renewal and be more insensitive to chemotherapy-induced differentiation.148O-GlcNAcylation, plays a pivotal role in modulating the activity of nuclear proteins involved in gene expression, signal transduction, and cell growth.149 High expression of O-GlcNAcylation of c-Myc promotes rapid proliferation of pre-B cells.