SOAT1 and neoplasm: The STAT protein family includes seven members, among which STAT5 plays an important function in the regulation of growth and development and tumor immunity.107O-GlcNAcylation promotes oncogenic transcription by enhancing STAT5 tyrosine phosphorylation and oligomerization to drive myeloid transformation.108 It was found that O-GlcNAcylation, a modification necessary for STAT5-induced transcription, occurs at Thr at the N-terminal site 92 of the STAT5 protein.109 Defective or hyperactive STAT5 variants of O-GlcNAcylation differ greatly in oncogenic potential.