Follicular lymphoma (FL) is a class of NHL originating from follicle-centered B-cells, with a typical immunophenotype of CD5-CD10 + CD19+ with t(14;18) (q32; q21), and whose BCR undergoes SHM to produce a high degree of tumor heterogeneity.163,164 FL cells undergo persistent somatic hypermutation in the variable region gene of their immunoglobulins. This evidence concerns the gene BCR and neoplasm.