FUT8 and neoplasm: This promotes apoptosis or initiates signaling pathways that are distinct from normal glycosylation.136 It has been illustrated that knockdown of FUT8 leads to the deletion of core fucosylation of FLT3, which results in sustained ligand-independent and autonomous activation of its downstream pathway and unlimited proliferation of tumor cells.137 2-Deoxy-D-glucose (2DG) could induce cell death by inhibiting the N-glycosylation of FLT3 in FLT3-ITD-mutated AML, decreasing the cell surface expression of FTL3-ITD.