OGT and obesity due to melanocortin 4 receptor deficiency: O-GlcNAcylation is also a nutrient-sensing response, and studies have shown that induced removal of OGT decreases O-GlcNAcylation levels of lipid droplet-associated perilipin 1, leading to enhanced visceral lipolysis.354 Targeting OGT emerges as a potential target for the treatment of obesity.