Studies have shown that aberrant expression of Notch-modified glycosyltransferase, including protein O-glucosyltransferase 1 (POGLUT1) and protein O-fucosyltransferase 1 (POFUT1), can be found increased in several diseases, such as oral squamous cell carcinoma.91 POGLUT1 functions as a protein-O-glucosyltransferase, facilitating the transfer of glucose to the EGF-like domains found in Notch receptors and other signaling receptors. This evidence concerns the gene POFUT1 and oral cavity squamous cell carcinoma.