TGFB1 and neoplasm: Sialylation-mediated regulations on TGF-β signaling are linked with epithelial-mesenchymal transition (EMT).116 ST3Gal1, a key sialyltransferase, could mediate sialylation of vasorin to facilitate TGF-β1-mediated angiogenesis and progression of tumor.117 In addition, GalNAc-type O-glycosylation is initiated by polypeptide N-acetylgalactosaminyltransferases, is involved in TGF-β signaling regulation.