FUT8 and cancer: However, excessive N-glycosylation of E-calmodulin weakens the adherens-junction.48,49 E-calmodulin N-glycosylation is mainly controlled by the GnT-III, GnT-V, and fucosyltransferase 8 (FUT8), which are involved in the regulation of cell-cell adhesion.50 Significant alterations in glycosylation have been observed for several cell adhesion molecules in the tumor microenvironment, predominantly cadherin, and selectins, becoming a common feature of cancer progression.