ST6GAL1 and familial pancreatic carcinoma: ST6Gal-I was demonstrated to enhance HIF-1α signaling, thereby protecting ovarian and pancreatic tumor cells against hypoxic stress.372 The glycosyltransferase ST6Gal-I is upregulated in ovarian and pancreatic cancers and expressed at high levels in metastatic tumors.373 In addition, the glycosylation patterns of glycoproteins associated with circulating extracellular vesicles, as well as mucins, present potential targets for the development of detection methods.