CD274 and diffuse large B-cell lymphoma: GLT1D1 transfers N-linked glycans to PD-L1, which was found to promote the immunosuppressive function of glycosylated PD-L1 and attenuates the cytotoxic function of T cells against lymphoma cells.183 Thus, inhibition of GLT1D1 activity may be a new therapeutic direction for DLBCL.