STAT1 and neoplasm: The study could observe that O-GlcNAcylation of Thr at the T58 site occurs with phosphorylation modification, which also serves as evidence that O-GlcNAcylation regulates gene transcription signaling in tumor cells.110 In addition, it was identified that the JAK/STAT1 pathway could act as a regulator of glycolysis, enhanced glucose turnover was associated with abundant STAT1-O-GlcNAcylation in mesenchymal stem cells.111 The above studies demonstrate the critical role of glycosylation in the JAK-STAT signaling pathway and reveal the possible functions involved in glycosylation.