The hippocampal neuronal model of AD (induced with 1 μM AβOs) was treated with 20 mM 3‐TYP, a SIRT3 inhibitor, and 10 μM HKL to verify whether HKL relieved damage to the hippocampal neuronal model of AD by regulating SIRT3. This evidence concerns the gene SIRT3 and Alzheimer disease.