A previous study has reported that HKL treatment can mitigate mitochondrial damage and increase the expression of autophagy markers such as LC3‐II, Parkin, and PINK1 in the hippocampus to relieve cognitive impairment in mice; however, treatment with 3‐MA, an autophagy inhibitor, abrogated these neuroprotective effects of HKL.63 This evidence concerns the gene PRKN and Cognitive impairment.