PRKN and Alzheimer disease: HKL treatment remarkably intensified the fluorescence staining of mitochondrial Parkin in the hippocampal neuronal model of AD (p < 0.001); however, this enhancing effect of HKL on the fluorescence intensity of mitochondrial Parkin was abrogated by 3‐TYP (p < 0.01) (Figure 7G,H) (Figure 7G: F = 162.4, df = 3).