Among the 15 genes, 13 genes linked to PSP from the AHBA database played a major role in enhancing PLS1 (refer to Table S8) of which nine genes (LRRK2, SNCAIP, SNCB, ATP1A3, DDC, PARK7, TH, HTRA2, and SLC6A3) showed positive correlations with MSN changes, while four genes (UCHL1, SNCA, NR4A2, and PINK1) showed negative correlations (all pspin <0.05, BH‐FDR corrected, Figure 3E and Figure S3). This evidence concerns the gene LRRK2 and supranuclear palsy, progressive, 1.