The effect of induction of cell cycle checkpoints p21 and p27 is more pronounced in 5-FU alone treated cells than in FAC-pretreated/5-FU-treated CRC cells (Fig. 6B, C), however, the decrease in protein expression of C-Myc, cyclin D1, and survivin is more in FAC-pretreated/5-FU-treated CRC cells than in 5-FU treated CRC cells (Fig. 6D–E). This evidence concerns the gene MYC and colorectal carcinoma.