That said, iron overload also induces oxidative stress leads to lipid peroxidation of the cell membrane, and disrupts several signaling pathways that eventually culminate in ferroptosis and cell death [9].A recent report has suggested that iron in combination with compound Kushen injections promotes chemosensitization of CRC cells by reducing TOP2A and p53 expression [10]. This evidence concerns the gene TP53 and colorectal carcinoma.