Consistent with previous observations, a significant increase in MMP depolarization as well as upregulation of mitochondrial resident apoptotic proteins Bak, Bax and downregulation of Bcl-xL expression in FAC-pretreated/5-FU-treated cells was consistently observed compared to untreated or FAC alone treated CRC cells [35]. Here, BCL2L1 is linked to colorectal carcinoma.