TPD52 and neoplasm: TPD52 was found to be dramatically elevated in CRC samples, independent of tumor localization, grading, and TNM staging.20 TPD52 overexpression induces the migration/invasion and epithelial-mesenchymal transition of CRC cells and serves as an independent predictor for reduced overall survival.19 We also observed that TPD52 overexpression enhanced the viability, invasion, and migration of CRC cells treated with KLF7 silencing, suggesting that TPD52 overexpression counteracted the inhibitory effect of KLF7 silencing on CRC cell invasion and migration.