KLF7 and colorectal carcinoma: 16,24,25 miR-139-5p weakens the stemness maintenance and depresses the epithelial-mesenchymal transition of CRC stem-like cells, implying the potential of miR-139-5p in the clinical treatment of recurrent and metastatic CRC.15 We found that miR-139-5p was notably diminished in CRC tissues and cells, and KLF7 silencing resulted in an increase in miR-139-5p expression.