CRC is a complex heterogeneous disease in which individuals may exhibit accumulation of somatic mutations at different stages, leading to malignant and invasive phenotypes in cells.3 A plenty of studies have pointed out the detrimental effects of KLF7 on carcinogenesis and cancer progression, including endometrial cancer,21 hepatocellular carcinoma,7 and CRC.10 We are the first to discover the mechanism of KLF7/miR-139-5p/TPD52 in CRC cell invasion and migration (Figure 7). This evidence concerns the gene TPD52 and hepatocellular carcinoma.