KLF proteins frequently exhibit dysregulated expression profiles in CRC and possess prominent prognostic values.5 A significant association between KLF7 mRNA and CRC recurrence has been observed in a published microarray dataset.22 The aberrant KLF7 overexpression magnifies the clonogenic activity of CRC cells and predicts dismal prognoses in CRC patients.10 Our data were consistent with the previously published findings that KLF7 was abundantly expressed in CRC and KLF7 silencing attenuated CRC cell invasion/migration and also restrained tumor growth in vivo. The gene discussed is KLF7; the disease is neoplasm.