CRC is a complex heterogeneous disease in which individuals may exhibit accumulation of somatic mutations at different stages, leading to malignant and invasive phenotypes in cells.3 A plenty of studies have pointed out the detrimental effects of KLF7 on carcinogenesis and cancer progression, including endometrial cancer,21 hepatocellular carcinoma,7 and CRC.10 We are the first to discover the mechanism of KLF7/miR-139-5p/TPD52 in CRC cell invasion and migration (Figure 7). The gene discussed is TPD52; the disease is colorectal carcinoma.