As reported, this variant can inhibit transcription in mammalian cells, such as PAI-2/SerpinB2.29 PAI-2 acts as a tumor repressor gene in several cancers, such as hepatocellular carcinoma, pancreatic cancer and NSCLC.30–32 Although the amino-truncated NOV protein was detected years ago, its sequence was not defined until now, and the role of NOV188-356aa in cancers was unknown. This evidence concerns the gene SERPINB2 and cancer.