MSI2 and familial pancreatic carcinoma: The mRNA levels of NLK showed the most significant changes in response to MSI2 knockdown and overexpression in pancreatic cancer cell lines, as observed in Capan-2 cells (MSI2-Ctrl VS MSI-Sg) and Panc-1 cells (Lv-Vector VS Lv-MSI2) (Fig. 1b).