designed an ex vivo mRNA delivery platform, C14-4/DOPE/Chol/PEG-lipid, by using ionizable lipid nanoparticles (LNPs) that can produce high quality of the CD19-CAR-T cells and elicit potent cancer-killing activity in Nalm-6 acute lymphoblastic leukemia cells [228]. The gene discussed is CD19; the disease is cancer.