KRAS and neoplasm: Some of our findings confirm other reports in the literature, for example, Wei et al. noticed up-regulation of RASSF8 in LUAD patients26; kucherlapati found that WIPI2 is over expressed in EGFR activated tumors27; Manenti et al. noticed the polymorphisms in KRAS and PTHLH loci were associated with tumor prognosis28.