KMT2C and neoplasm: Nevertheless, hub genes of cluster 6 are TIF1A (transcription intermediary factor 1 α), known to interact with numerous proteins involved in chromatin structure82 and MLL3, a mono-methyltransferase that targets lysine 4 (Lys4) from histone 3 (H3K4), an epigenetic mark that has been related to enhancer elements involved in the activation of tumor suppressor genes83.