Specifically, the enhanced infiltration of cytotoxic T cells, Natural Killer cells and anti-tumor macrophages (M1 macrophages) in 7.16.4 mAb/Cpt1a-inhibited tumors aligns with their role in tumor elimination, including ADCC engagement, in ErbB2+ breast cancer, where their presence may correlate with favorable outcomes83–86. The gene discussed is ERBB2; the disease is breast cancer.