Cpt1a ablation led to elevated Nrf2 expression at the protein and mRNA levels in tumor cells in vitro and in vivo (Fig. 4d and Supplementary Fig. 6b), and we validated the elevated expression of Nrf2 regulated genes in Cpt1a-deficient NIC cells compared to controls (Fig. 4e). The gene discussed is CPT1A; the disease is neoplasm.