Interestingly, the ketogenic diet increased tumor size and decreased survival in mice bearing wild-type ErbB2+ tumors, consistent with the efficient use of lipids and ketone bodies as metabolic fuels for NIC/Cpt1a+/+ tumor cells in vitro and in vivo (Fig. 6d–f, and Supplementary Fig. 10c). This evidence concerns the gene ERBB2 and neoplasm.