The overexpression of OTUD3 inhibited apoptosis and CASP3/7 activity in DLBCL cells while knocking down OTUD3 promoted apoptosis and CASP3/7 activity in these cells (Figs. 1F–H, S1L–N, S2A–D). The gene discussed is OTUD3; the disease is diffuse large B-cell lymphoma.