Subsequently, OTUD3 knock-down may promote P21 expression by enhancing p-MDM2 mediated P53 phosphorylation levels, further reducing the downstream expression of CDK2 and Cyclin E1, thereby forcing DLBCL cells to arrest in the G1/G0 phase (Figs. 1N, S3A). The gene discussed is MDM2; the disease is diffuse large B-cell lymphoma.