SYT13 and amyotrophic lateral sclerosis: The transcripts identified with this approach were mainly related to stress response pathways as well as vesicular/lysosomal structures (Fig. 4C), and network analysis highlighted some important molecules involved in neuronal cell death (such as members of the caspase family) and of the immune response (like interleukins and heat-shock proteins) as major determinants of the overlap between SYT13+/− and ALS signatures (Fig. 4D).