Since the RNAseq analysis highlighted a striking resemblance of ALS features when the levels of SYT13 are reduced in MNs, we confronted the SYT13+/− transcriptome with the one of mutant MNs obtained from patients with mutations in C9orf72, FUS, TARDBP, and SOD1 genes [32]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.