Accordingly, we found that the expression of SYT13 was significantly altered in transcriptional signatures (Fig. 4F; Supplementary Table 1D) linked to TP53 activation and ALS, and the top up-regulated genes linked to mimicker signatures of SYT13 were involved in toll-like receptor signaling and pro-apoptotic pathway (Fig. 4G). Here, TP53 is linked to amyotrophic lateral sclerosis.