Functional enrichment analysis showed that the up-regulated interactors were associated with GO-BP terms related to protein metabolic processes and signalling, while the down-regulated interactors, similar to the LRRK2-PD condition, were predominantly related to biosynthetic processes and ribosome biogenesis (Fig. 2B, C, Table S4). The gene discussed is LRRK2; the disease is Parkinson disease.