Univariate logistic regression was performed on each of the 109 LRRK2 interactors with significant differential expression in the sPD and/or LRRK2-PD cohorts vs. controls, out of which 11 interactors with p-value < 0.05 were selected for further model construction, including TUBB6, SNCA, HSPA1A, BAG3, ACTA2, TUBG1, LMNB1, CDK2, RAB5B, LRRK2 and SLC25A6 (Table S5). This evidence concerns the gene ACTA2 and Parkinson disease.