LRRK2 and Platelet storage pool disease: Additionally, polymorphisms, mainly in the promoter of LRRK2 and proposed to modulate expression of LRRK2, have been linked to lifetime risk of developing sporadic PD (sPD) (Nalls et al. 16), while upregulated LRRK2 kinase activity (in the absence of pathogenic mutations) has also been related with sPD.