LRRK2 and Parkinson disease: Among the 11 clusters, Cluster A was significantly altered (down-regulated) in both sPD and LRRK2-PD cases vs. controls (p < 0.05), with 72/115 (62.6%) and 57/115 (49.5%) edges down-regulated, respectively (Fig. 7B, C, Fig. 8A).