When we carried out a functional analysis of the 109 significantly-altered LRRK2 interactors, we found that proteins up-regulated in the LRRK2-PD condition were mainly related to cytoskeletal dynamics and transport, while those up-regulated in the sPD condition were associated with signalling and protein metabolic processes, again suggesting divergent functional profiles for the LRRK2int in the PD scenario depending on the presence/absence of the LRRK2G2019S mutation. Here, LRRK2 is linked to Parkinson disease.