As early as 2009, Mirza et al. conducted a large-scale cohort study to explore the relationship between FGF23 and vascular endothelial function and atherosclerosis and found that elevated FGF23 was associated with impaired endothelium-dependent and endothelium-independent vasodilation in a natural population aged ≥ 70 years.11 This evidence concerns the gene FGF23 and atherosclerosis.