The structure and function of the key gene ATP5B are closely related to mitochondrial morphology, which can regulate mitochondrial fission and fusion in mammalian cells,20 and serve as a predictive marker for the prognosis of patients with various diseases such as colorectal cancer and gallbladder cancer,21,22 can also be considered as a reference marker for T2DM. Here, ATP5F1B is linked to type 2 diabetes mellitus.