Mutations in various genes related to the pathogenesis of PD(such as α-synuclein [19, 20], PINK1 [21, 22], Parkin [23, 24], DJ-1 [25], LRRK2 [17, 26], ATP13A2 [27], HTRA2) lead to impaired mitophagy and disrupt mitochondrial homeostasis. Here, PRKN is linked to Parkinson disease.