The heart is commonly involved in ATTRv‐PN,36 especially in the late‐onset phenotype.5, 8 Our previous study demonstrated that the majority of our ATTRv‐PN patients had a comorbidity of cardiomyopathy with significant radiotracer uptake in the heart on 99mTc‐PYP SPECT imaging, abnormally increased thickness of the IVSd and LVPWd on echocardiography, and increased pro‐BNP in the blood.4 This evidence concerns the gene NPPB and cardiomyopathy.