PRNP and Creutzfeldt Jacob disease: While cellular prion proteins (PrPC) naturally occur in the plasma membrane of cells in vertebrates, the infectious conformer (PrPSc) stimulates PrPC to misfold, resulting in accumulation of PrPSc eventually leading to invariably fatal neurodegeneration of infected hosts [1].TSEs affect both, humans (e.g. Creutzfeldt-Jakob-Disease, CJD) and animals.