Bloom syndrome, stemming from BLM RecQ Like Helicase gene mutations affecting DNA helicase, is characterized by short stature, a photosensitive rash, immunodeficiency, an elevated risk of tumors, and hypogonadism [49]; Werner syndrome, a typical human premature aging syndrome, results from WRN RecQ Like Helicase gene mutations. This evidence concerns the gene RECQL and hypogonadism.