The tumor microenvironment plays integral roles in cancer and metastasis through many mechanisms: immunosuppression through secretion of anti-inflammatory cytokines (e.g., IL-10) by tumor-associated macrophages [231, 232], promoting migratory phenotypes through activation of pathways such as Wnt and EGFR [233, 234], induction of hypoxia and secretion of pro-angiogenic factors [235, 236], and promoting chemoresistance [237]. Here, EGFR is linked to neoplasm.