The zinc-finger E-box binding homeobox proteins 1 and 2 (ZEB1/2) have also been implicated in EMT; in vitro prostate cancer models revealed that ZEB1 binds to the E-cadherin promoter and recruits the histone deacetylase Sirtuin-1, resulting in histone deacetylation and repression of E-cadherin [205]. This evidence concerns the gene CDH1 and Familial prostate cancer.