Pathway enrichment analyses of DETGs revealed that the p53 signaling pathway, microRNAs involved in cancer, the cell cycle, EGFR tyrosine kinase inhibitor resistance, gastric cancer, cellular senescence, oocyte meiosis, and Cushing syndrome were the top 10 enriched KEGG pathways (Fig. 3D). The gene discussed is TP53; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.