The latest breakthrough from our team has illuminated the newly founded genetic characteristics of IBD in East Asian ancestry, including macrophage-related genes like RUNX family transcription factor 3 (RUNX3), IL21R, general transcription factor Iii (GTF2I), and leukocyte immunoglobulin like receptor B3 (LILRB3) [17]. Here, GTF2I is linked to inflammatory bowel disease.