ARG2 and Crohn disease: In addition, macrophage-associated gene arginase-2 (ARG2) is increased in inflamed intestinal mucosa as well as intestinal accessory tissues (i.e., mesenteric adipose tissue, mesentery, and mesenteric lymph nodes) from Crohn’s disease patients [13], and it is found to be localized at the mitochondria and upregulated by the IL-10/miR-155 axis in pro-inflammatory macrophages, thus contributing to the enhancement of oxidative phosphorylation via the suppression of HIF-1α and IL-1β in inflammatory macrophages [156].