Previous studies have highlighted that copious amounts of IBD susceptibility genes are related to the monocyte-macrophage lineages like nucleotide binding oligomerization domain containing 2 (NOD2), autophagy related 16 like 1 (ATG16L1), C-X3-C motif chemokine receptor 1 (CX3CR1), Janus kinase 2 (JAK2), and signal transducer and activator of transcription 3 (STAT3) [14–17]. This evidence concerns the gene STAT3 and inflammatory bowel disease.