Also, Silveira et al. [18] working on HF cows, Czerniawska-Piątkowska et al. [48] working on Holstein and Jersey cows [20] working on Madura cattle and Hartanto et al. [29] working on Jawa-Brebes cows, and obtained differentiated milk yield and composition and reproductive performance in response to different IGF-I and GH genotypes. The gene discussed is IGF1; the disease is hydrops fetalis.