IFNG and cancer: In GSEA, TPST2 knock-down resulted in the depletion of cell cycle-related genes, such as ‘E2F_TARGETS’, ‘G2M_CHECKPOINT’, ‘MYC_TARGETS’, and ‘MITOTIC_SPINDLE’ (Fig. S8e), which is suggestive of enhanced IFNγ signaling, because IFNγ signaling is involved in the anti-proliferative effect on the cancer cells [23].