SOAT1 and human papilloma virus infection: We selected 22 genes with multiple depleted sgRNAs in anti-PD1-treated mice (Fig. S3) and mapping these genes onto the STRING protein-protein interaction networks also demonstrated a highly connective network enriched in immune-related pathways, including ‘Cell adhesion molecules (CAMs)’, ‘Human papillomavirus infection’, and ‘Jak-STAT signaling pathway’ (P < 0.05, Fig. 1e).