Breast cancer tissues with high TPST2 expression demonstrated the enriched expression of cancer aggressiveness-related gene sets such as ‘EPITHELIAL_MESENCHYMAL_TRANSITION’ (Fig. 6d-f) and depleted expression of cell cycle checkpoint-related gene sets such as ‘E2F_TARGETS’, ‘G2M_CHECKPOINT’, and ‘MITOTIC_SPINDLE’ (Fig. S18b-d). Here, TPST2 is linked to breast cancer.