As shown in Table 2, genes such as ACE2, BMP3, BPIFB1, CCL17, CCL22, CLU, CST6, CTF1, FBLN1, HMGB2, MMP12, PDGFA, PLAU, RNASE7, S100A7, S100A8, S100A9, SULF2, and TGM2 primarily function in regulating immune responses to exert anti-tumor and anti-infection effects. This evidence concerns the gene HMGB2 and neoplasm.