In addition, IL-32 helps to induce other pro-inflammatory mediators, such as procoagulant, pro-inflammatory and cytokine effects of IL-1 β when siRNA reduces IL-32 levels, such as IL-1 β-induced ICAM-1 production, which also significantly reduces the up-regulation of ICAM-1 in human umbilical cord endothelial cells (HUVECs) induced by IL-1 β, so it is considered that IL32 plays an important role in the process of atherosclerosis [35, 36]. Here, ICAM1 is linked to atherosclerosis.