In the subgroup analysis for tumours with both ER and PR positivity, tumour grade was a significant prognostic indicator for both grade II versus I (HR 2.14, 95% CI 1.30, 3.52) and grade III/IV versus I comparisons (HR 2.77, 95% CI 1.67, 4.60). The gene discussed is PGR; the disease is neoplasm.