Pokemon protein, known for its diverse roles in various human carcinomas, including non-small cell lung cancer, laryngeal squamous cell carcinoma, and liver cancer (Gao et al. 2013; Koken et al. 1997; Liu et al. 2013; Zhao et al. 2008, 2014), has been implicated with the development and progression of CRC (Wang et al. 2010; Zhao et al. 2013). This evidence concerns the gene ZBTB7A and liver cancer.