We also investigated the association of CLDN18.2 expression and the molecular features of GC, including the statuses of mismatch repair (MMR), Epstein-Barr virus (EBV), human epidermal growth factor receptor 2 (HER2), and programmed cell death ligand 1 (PD-L1) (Fig. 1D). This evidence concerns the gene CD274 and gastric cancer.