HOXB4 and neoplasm: Interestingly, Kron et al. (2009)20 identified several homeobox genes as differentially methylated between high and low Gleason score tumours; whilst we did not replicate these particular genes, four other homeobox genes, HOXC12, HOXB9, HOXB4 and HOXA3, were highlighted, with 10 significantly dmCpGs present in the HOXA3 gene.