Interestingly, Kron et al. (2009)20 identified several homeobox genes as differentially methylated between high and low Gleason score tumours; whilst we did not replicate these particular genes, four other homeobox genes, HOXC12, HOXB9, HOXB4 and HOXA3, were highlighted, with 10 significantly dmCpGs present in the HOXA3 gene. This evidence concerns the gene HOXC12 and neoplasm.