There was also a non-statistically significant reduction in the mRNA levels of other pro-inflammatory mediators, including Tnfa, Il1b, Cox2, and two chemokines previously found reduced in response to hypercholesterolemia in vivo, Cxcl9 and Cxcl10 (Fig. 7F)43. Here, CXCL10 is linked to familial hypercholesterolemia.