Second, we performed ultra-deep targeted long-read sequencing of transcripts expressed from 20 genes previously implicated in AD and other neurodegenerative disorders (Table 1) in tissue from WT and TG mice at four time points (2, 4, 6 and 8 months) to identify differentially expressed transcripts (DETs) in the EC associated with tau pathology progression. The gene discussed is MAPT; the disease is Alzheimer disease.