We targeted genes affected by autosomal dominant mutations associated with neurodegenerative disorders (App, Mapt, Snca, Fus, Tardbp), genes identified from both AD genome-wide association studies (GWAS) (Abca1, Abca7, Apoe, Bin1, Cd33, Clu, Picalm, Ptk2b, Sorl1, and Trem2) and epigenome-wide association studies (EWAS) (Ank1, Rhbdf2), in addition to several genes implicated in related neurodegenerative phenotypes (Fyn, Trpa1, Vgf). The gene discussed is PICALM; the disease is Alzheimer disease.