To enable a more comprehensive AS analysis associated with tau pathology, we therefore performed ultra-deep long-read cDNA sequencing on a targeted panel of 20 genes previously implicated in AD (Table 1) in a larger number of WT and TG mice spanning four time-points (n = 24, 3 WT and 3 TG at ages 2, 4, 6 and 8 months, Supplementary Data 1). The gene discussed is MAPT; the disease is Alzheimer disease.