The down-regulated mouse LR.Bin1.99 (Bin1-201) isoform shows high homology with the human BIN1 isoform 1 (ENST00000316724.10, 87.2% homology, 79% query cover) that is significantly down-regulated in AD, whereas the up-regulated mouse LR.Bin1.224 (Bin1-205) isoform shows high homology to the human BIN1 isoform 9 (ENST00000409400.1, 88.2% homology, 50% query cover) that is significantly up-regulated in AD (Supplementary Fig. 17). This evidence concerns the gene BIN1 and Alzheimer disease.