The guidelines suggest focusing on preserving renal function through the normalization of blood pressure and proteinuria with the use of inhibitors of the renin-angiotensin-aldosterone system, treating anemia with erythropoiesis stimulators, taking care of energy adequacy, including the use of an enteral tube or gastrostomy when necessary, correcting hydro-electrolytic and acid-base disturbances, controlling PTH levels in the target range of CKD, using recombinant GH when indicated, and early kidney transplantation with immunosuppression protocols with minimal doses of steroids30. This evidence concerns the gene REN and chronic kidney disease.