PPG was significantly lower following a high-fat meal including cranberries at 2 h and 4 h in comparison to control (P < .05).Serum insulin and insulin resistance, as assessed by HOMA-IR, did not differ between interventions.Postprandial lipid profiles (TG, LDL-C, HDL-C, TC, and LDL:HDL ratio) were not statistically different following either meal at any time point.Biomarkers MDA and serum IL-18 were significantly reduced at 4 h (P < .05) following the cranberry meal vs control. This evidence concerns the gene INS and Insulin resistance.