Together, our proteome and transcriptome analysis of Cox10−/− and Cox10−/−Opa1v1Δ4 hearts suggests that disbalanced mitochondrial biogenesis and mitophagy limit cardiac hypertrophy (Fig. 6H), which is primarily a compensatory reaction to physiological stress, but almost inevitably leads to decompensation if stress persists, resulting eventually in cardiac failure. This evidence concerns the gene COX10 and heart failure.