MYC and cancer: Dubiella et al., 2021 have recently developed a unique inhibitor targeting peptidyl-prolyl isomerase NIMA-interacting-1 (PIN1), an upstream regulator of MYC activation (). PIN1 itself is frequently upregulated in many types of cancers, resulting in sustained proliferative signaling and tumor growth (Farrell et al., 2013; D’Artista et al., 2016). The PIN1 inhibitor, Sulfopin, was shown to downregulate MYC target genes in vitro and to block MYC-driven tumors in murine models of neuroblastoma (Dubiella et al., 2021).