CDKN1A and neoplasm: Importantly, we also confirmed that the combined treatment with Sulfopin and Vorinostat led to induction of p21 (CDKN1A), a prominent tumor suppressor promoting cell cycle arrest and regulated by mTOR signaling (Shamloo and Usluer, 2019; Tahmasebi et al., 2014; Cui et al., 2021; Figure 2H and J).