CD4 and coinfection: In contrast to previous systematic review findings [53, 55] and primary studies reported [12, 17, 32, 33, 38, 57–60] this meta-regression found no significant association between declined CD4 count (≤200 cells/cml), age of patients, duration of follow-up, comorbidity status, and functional status with the risk developing active TB in HIV co-infection children.