Pooled HRs of multivariate Cox regression indicated that higher ECOG score (HR=2.06, 95% CI=1.26–3.37), larger tumour size (>5 cm) (HR=1.86, 95% CI=1.12–3.10), heavier tumour burden (>50%) (HR=2.32, 95% CI=1.33–4.02), the existence of MVI (HR=1.60, 95% CI [1.19–2.14]) or EHS (HR=1.65, 95% CI [1.36–2.00]) and AFP >400 ng/ml (HR=1.52, 95% CI=1.20–1.92) were independent risk factors for patients’ OS. This evidence concerns the gene AFP and neoplasm.