TP53 and cancer: The CCDC106 protein, was previously known as HSU79303, which contained a coiled coil domain.[32] Members if the CCDC family promote tumor cell proliferation, while high levels of CCDC protein are associated with poor outcomes.[33] Previous studies have shown that a functional CCDC106 gene can not only promote the degradation of TP53/p53 proteins but also inhibit their trading activities.[34] TP53, a tumor suppressor, is involved in DNA damage and cell cycle regulation.[35–38] P53 dysfunction was found to promote cancer development and progression.