ACSL4 and cardiovascular disorder: AS is caused by iron deposition and lipid peroxidation in vascular endothelial cells.[62,63] Studies on ferroptosis in cardiovascular diseases have shown that multiple signaling factors are either directly or indirectly involved in iron ptosis, thus affecting iron metabolism and lipid peroxidation.[64] Iron ptosis has recently emerged as a therapeutic target in cardiovascular diseases.[65] Results of the present study showed that genes associated with iron ptosis (ACSL4, CBS, FTH1, and TFRC) were differentially expressed between the diseased and control groups.