SPON1 (F-spinin) belongs to thrombospondin, which contains thrombospondin type 1 repeat involved in matrix tissue and cell–cell interaction.[54,55] HsamiR-188-5p and SPON1 play a role in angiogenesis.[56,57] Some studies have shown that SPON1 is not only a sensitive plasma biomarker for myocardial infarction,[58] but is also significantly correlated with adverse clinical outcomes in CHF patients. This evidence concerns the gene SPON1 and congestive heart failure.