HTR2A and lung cancer: Studies indicate that administering 5-HT2 antagonists in buprenorphine-induced hyperalgesia resulted in reduced activation of astrocytes and reversal of buprenorphine-nduced hyperalgesia.[6] Jiang S et al demonstrated in their case report that administering duloxetine to a lung cancer patient with severe pain significantly reduced the amount of opioids required for pain relief and completely reversed OIH.[11]