The neonatal incidence rate of SMA in parts of East Asia is 0.51 to 0.58/10,000,[1,2] with a population carrier rate of 1/50.[3] Biallelic SMN1 mutations cause SMN protein insufficiency and α-motor neuron apoptosis in the anterior horn of the spinal cord. The gene discussed is SMN1; the disease is proximal spinal muscular atrophy.